Escherichia coli Nissle 1917 (EcN) strain is a Gram-negative strain isolated from a young German soldier who were not infected with Shigella during the endemic period at World War I. The probiotic drug Mutaflor ® using this EcN is available and used in managing gastrointestinal disorders including diarrhea, uncomplicated diverticular disease In the probiotic Escherichia coli strain Nissle 1917 and its recent clonal isolates, CsgD activates the production of curli fimbriae at 28 degrees C, but neither CsgD nor AdrA is required for the c-di-GMP-dependent biosynthesis of cellulose at 28 degrees C and 37 degrees C. the probiotic Escherichia coli (E. coli), Nissle 1917, to secrete proteins of therapeutic value into its surroundings. When engineered to secrete an antibody that blocks inflammation, this Huff, G. R. et al. Oral treatment with the probiotic Escherichia coli Nissle 1917 improves body weight and modulates the stress response of poultry in respiratory challenges with avian pathogenic Abstract. A century ago, Alfred Nissle discovered that intentional intake of particular strains of Escherichia coli could treat patients suffering from infectious diseases. Since then, one of these strains became the most frequently used probiotic E. coli in research and was applied to a variety of human conditions. DOI: 10.1128/JB.186.16.5432-5441.2004 Corpus ID: 24216238; Analysis of the Genome Structure of the Nonpathogenic Probiotic Escherichia coli Strain Nissle 1917 @article{Grozdanov2004AnalysisOT, title={Analysis of the Genome Structure of the Nonpathogenic Probiotic Escherichia coli Strain Nissle 1917}, author={Lubomir Grozdanov and Carsten Raasch and Jürgen Schulze and Ulrich Sonnenborn and 益生菌 Escherichia coli Nissle1917功能研究进展. 大肠埃希菌Nissle1917，简称EcN，是益生菌中为数不多的革兰氏阴性菌，在临床上主要用于克罗恩病、溃疡性结肠炎等胃肠功能障碍。. 其机制在于EcN能在人体肠道定殖，并阻止病原菌对肠道黏膜的侵袭，对肠道黏膜屏障 Mechanisms of colonization resistance. In 1917, as war was tearing its way across Europe, a fascinating scientific observation was being made. The German physician Alfred Nissle had been looking zG1IgJz.